Aquaporin complex regulating urine concentration
نویسندگان
چکیده
منابع مشابه
Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.
Concentration of urine in mammals is regulated by the antidiuretic hormone vasopressin. Binding of vasopressin to its V2 receptor leads to the insertion of water channels in apical membranes of principal cells in collecting ducts. In nephrogenic diabetes insipidus (NDI), the kidney fails to concentrate urine in response to vasopressin. A male patient with an autosomal recessive form of NDI was ...
متن کاملSevoflurane anaesthesia causes a transient decrease in aquaporin-2 and impairment of urine concentration.
Sevoflurane anaesthesia is occasionally associated with polyuria, but the exact mechanism of this phenomenon has not been clarified. Aquaporin-2 (AQP2) is an arginine vasopressin (AVP)-regulated water channel protein localized to the apical region of renal collecting duct cells and is involved in the regulation of water permeability. To elucidate the effect of sevoflurane anaesthesia on urine c...
متن کاملUrine concentration in depressive illness.
A total of 132 urine specimens were obtained from 17 depressed patients and 18 controls under conditions of mild water deprivation. Mean values of milliosmoles of solute and millilitres of urine excreted per hour were obtained for each subject. The depressed patients excreted significantly less solute than the control group per unit volume of urine. There was no significant difference between t...
متن کاملHigh-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.
A reduction or loss of plasma membrane aquaporin 2 (AQP2) in kidney principal cells due to defective vasopressin (VP) signaling through the VP receptor causes excessive urine production, i.e., diabetes insipidus. The amount of AQP2 on the plasma membrane is regulated by a balance of exocytosis and endocytosis and is the rate limiting step for water reabsorption in the collecting duct. We descri...
متن کاملDownregulation of renal vasopressin V2 receptor and aquaporin-2 expression parallels age-associated defects in urine concentration.
Renal concentrating ability is known to be impaired with aging. The antidiuretic hormone AVP plays an important role in renal water excretion by regulating the membrane insertion and abundance of the water channel aquaporin-2 (AQP2); this effect is primarily mediated via the V2 subtype of the AVP receptor (V2R). This study evaluated the hypothesis that decreased renal sensitivity to AVP, with s...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2012
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.139.66